Three men are accused of being part of a criminal syndicate that imported almost 750 kilos of methylamphetamine in shipping containers into Sydney.
Acting on a tip off, Australian Border Force officers found the haul secreted in numerous sea cargo containers which arrived at Port Botany last month.
Police say the 748kg of methylamphetamine has an estimated potential street value of more than $675 million.
Detectives from the NSW Drug and Firearms Squad arrested three men over the stash on Wednesday.
They were all refused bail to appear at court later on Thursday.
NSW Police Commissioner Karen Webb will be joined by senior officers from State Crime Command and Australian Border Force to address the media about the bust later on Thursday.